Top2a

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August undefined, 2024

Web14. okt 2024 · A human TOP2A core DNA binding X-ray 的功能相一致，两种酶在不同细胞中的表达也各有 structure reveals topoisomerase subunit dynamics and a po- 差异。除了各自的不同功能，两种亚型在胚胎向神 tential mechanism for SUMO modulation of decatenation. WebTOP2A was reported to be one of the top 10 hub genes identified in BCa, along with VEGFA, CCNB1, CDC20, AURKB, UBE2C, and CCNB2 [187]. Furthermore, S. Zeng et al. found that TOP2A was highly ...

DNA 拓扑异构酶 II α（TOP2A）基因 MCE

Web进而，利用小分子化合物抑制 Bub1 的激酶活性后， TOP2A 在着丝粒的定位几乎消失（图 2B ），说明 Bub1 的激酶活性对于 TOP2A 的着丝粒定位是必需的。图 2 ：敲减 Bub1 的表达（ A ）或利用小分子化合物抑制 Bub1 的激酶活性（ B ）去除 TOP2A 在有丝分裂前中期染色体 … Web在该细胞中，增殖和干细胞标志物（如Top2a，Birc5，Cldn6和Mki67）高度表达，而分化和top-crypt标志物（如Muc2，Ms4a8a和Epcam）则不存在。CT26.WT细胞与侵袭性、未分化、难治性人结肠直肠癌细胞有着共同的分子特征。 five plateforme

Regulation of TOP2A. (a) Domain arrangement of TOP2A. TOP2A …

Webtop2a是蒽环类药物的作用靶点，近年的研究普遍认为top2a与her-2基因共表达的患者可以从蒽环类化疗中获益，hertel等的研究表明her-2阴性但top2a高表达的患者，使用蒽环类药物同样可以从临床治疗中获益。 WebDNA topoisomerase II, alpha isozyme, TOP2A, DNA topoisomerase 2-alpha, TOP2. Species. Human . Shipping. In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers … can i use freezer burned meat

TOP2A概述_百度文库

WebTOP2A. 这个基因编码一种DNA拓扑异构酶，这种酶在转录过程中控制和改变DNA的拓扑状态。. 这种核酶参与诸如染色体凝聚、染色单体分离以及DNA转录和复制过程中发生的扭转 … http://antibodysystem.com/product/11952.html can i use free lateral flow test for day 2WebACROBiosystems中国为您提供TOP2A分子靶点蛋白信息和蛋白产品以及其上市抗体药物信息、和临床药物信息，临床试验等信息，方便您的药物研发。 400-682-2521 [email protected] 注册登录 can i use fresh corn husks for tamales

"WebThis antibody detects endogenous levels of Human TOP2A (Phospho Ser1213) Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Source: Rabbit: Dilution: WB 1:1000-2000 ELISA 1:5000-20000: Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. " - Top2a

Top2a

Web2. jún 2024 · Topoisomerase IIα (TOP2A) is a core component of mitotic chromosomes and important for establishing mitotic chromosome condensation. The primary roles of … Web• TOP2a突变是否可能成为乳腺癌的一个亚型？讨论二 • TOP2a蛋白 • TOP2a蛋白高表达是否是预后不良的预测指标？ A. 是 B. 否 • 您认为对于乳腺癌，TOP2a蛋白是否可能与Ki67具有同样的价值？ A. 是 B. 否 • 对于TOP2a蛋白高表达患者，您现在会尝试首选哪个化疗 ...

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Web2. jan 2024 · top2a是一种控制dna拓扑状态的酶，可催化双链dna断裂并促进有丝分裂期间的基因转录。top2a通过zeste同源物2的增强子参与表观遗传的调控，top2a的异常表达与肿瘤的恶性特征相关。在kegg通路富集分析中mcm2、pcna和ccna2富集于细胞周期相关通路。 Web阿霉素和top2a的dna结合，破坏癌细胞dna双链形式，造成dna断裂。这会触发细胞凋亡，细胞自杀机制，防止细胞的生长。 Yeh和他的同事们发现，这种药物结合心肌细胞的Top2b，但却以不同的方式攻击癌细胞。

WebTOP2A Antibodies. Antibodies that detect TOP2A can be used in several scientific applications, including Western Blot, Immunohistochemistry, Immunocytochemistry, Immunoprecipitation and ELISA. These antibodies target TOP2A in Human, Mouse and Rat samples. Our TOP2A monoclonal, polyclonal and recombinant monoclonal antibodies are … Web10. dec 2024 · TOP2A is a direct target gene for miR-144-3p, and TOP2A promotes the proliferation and migration of glioma cells. Overexpression of miR-144-3p suppresses the growth of glioma xenografts in nude mice. These data suggest that miR-144-3p is likely to inhibit proliferation by targeting TOP2A in HCMV-positive glioblastoma.

WebPred 1 dňom · Anthracycline plus taxane regimens are most efficacious at reducing breast cancer recurrence and death. Regimens with higher cumulative doses of anthracycline plus taxane provide the greatest benefits, challenging the current trend in clinical practice and guidelines towards non-anthracycline chemotherapy, particularly shorter regimens, such … http://www.caregeno.com/about2.php?cid=186

Web24. okt 2024 · MF4：在靶向治疗的三个时间节点上无明显规律，该cluster表达了增殖的髓系细胞基因(TOP2A, MKI67)。 T/NK细胞(n = 2,226)进一步聚类，细分成5个亚群并，进行marker基因的注释(图C-D)。在RD肿瘤中，T细胞总体比例较高(图4C)，且没有单个T细胞亚簇在RD中富集。

WebPCA降维可视化. 我们使用FindVariableFeatures函数筛选出的高变异基因进行PCA降维可视化，可以发现尽管大多数变异都能被解释，但是在PC8和PC10中存在一些细胞周期基因，如TOP2A和MKI67。因此，我们试图通过回归处理减少细胞周期异质性对下游分析的影响。 can i use freezer paper for sublimationWeb27. mar 2024 · Topoisomerase II alpha (TOP2A) is encoded by the TOP2A gene located on chromosome 17q12-q21. It is a key nuclear enzyme for controlling of topological states of … five plasmodium speciesWeb15. jan 2024 · TOP2A may be a new biomarker and therapeutic target for hepatocellular carcinoma. Hepatocellular carcinoma (HCC) is a primary liver cancer with a high mortality rate. However, the molecular mechanism of HCC formation remains to be explored and studied. To investigate the expression of TOP2A in hepatocellular carcinoma (HCC) and … can i use fresh wood chips for mulchWeb28. dec 2024 · The sequence of 1 of the TOP2A cDNAs is identical to that of an internal fragment of the TOP2 cDNA isolated by Tsai-Pflugfelder et al. (1988). Southern blot analysis indicated that the TOP2A and TOP2B cDNAs are derived from distinct genes. Northern blot analysis using a TOP2A-specific probe detected a 6.5-kb transcript in the human cell line … five player coop gamesWebTOP2A overexpression significantly correlates with more advanced AJCC stages and independently predicts worse DSS and DMFS. TOP2A is highly overexpressed in … can i use fresh oregano instead of driedWeb29. jún 2024 · 在pca后，会发现pc8与pc10中包括top2a和mki67的细胞周期mark。可以尝试数据中回归该信号，避免影响下游分析。三、获取细胞周期分数. 首先，我们根据每个细胞的g2 / m和s期标志物的表达为其分配分数。 five plate stoveWebTOP2A is a key player in the decatenation checkpoint, and depletion leads to chromosomal mis-segregation. TOP2A is highly expressed in the G2 and M phases of the cell cycle … five please